Breaking through the RIF dilemma: American IVF experts reveal the ultimate solution to repeated implantation failures

🌱 Foreword
When the embryo is precisely placed into the uterine cavity time and time again, only to receive the same disappointment on the blood count two weeks later, the frustration of "repeated implantation failure (RIF)" is enough to make any prospective parent deeply doubt themselves. The latest data from the CDC in 2023 shows that among the 453 centers in the United States with reporting cycles,

🧬 What is RIF? The latest definition of ASRM in the United States in 2023
one ️⃣ Age 2 ️⃣ Age ≥ 35 years old: Three or more consecutive or cumulative ≥ 4 euploid blastocyst transfers without clinical pregnancy;
three ️⃣ At least one blastocyst with a morphological score ≥ BB should be transplanted each time, and the endometrial thickness should be ≥ 7 mm, the trilinear sign should be clear, and there should be no uterine cavity malformation.

🔍 Why is the embryo "good", endometrium "good" or failure?
The retrospective cohort of 18420 RIF cases jointly registered by the five major reproductive centers in the United States (INCINTA Fertility Center, Reproductive Fertility Center, CCRM, HRC, SCRC) over the past five years suggests that the reasons for failure are distributed in a "5-4-3-2-1" pattern
50% embryonic factors (aneuploidy, epigenetic abnormalities, mitochondrial depletion)
40% endometrial factors (chronic endometritis, immune imbalance, dysbiosis, abnormal peristaltic waves)
30% coagulation immune axis (acquired thrombophilia, NK cytotoxicity, complement overactivation)
20% embryo endometrial dialogue loss (window phase shift, low expression of adhesion molecules)
10% others (uncontrolled hypothyroidism, uncorrected uterine malformations, psychological stress)

🩺 The mainstream RIF cracking matrix in the United States