What are the advantages behind the soaring number of test tube babies going to the United States that you must know?

In the past three years, despite tight international flight seats and visa reservations being delayed for six months, the number of Chinese families traveling to the United States for assisted reproduction has risen against the trend. The latest Annual Report on Assisted Reproductive Technology released by the Centers for Disease Control and Prevention (CDC) in the United States shows that the number of cycles from China has increased by 62% compared to before the epidemic, accounting for 38% of all overseas medical cycles in the United States, ranking first. Why are more and more families willing to cross half the globe to initiate IVF in the current environment full of uncertainty? The answer is hidden in a repeatedly verified '; Value Formula "; Inside: Technology maturity x Laboratory standards x Legal transparency x Individualized solutions x Long term security tracking. When this formula is compared horizontally globally, the United States gives higher scores after almost every multiplication sign, so; Going to the United States "; From the adventure of a few people to the rational choice of the majority.

The table above only lists'; Visible "; The differences that truly make families make up their minds are those; Cannot see; But it concerns the sense of security for the next few decades: once a rare medical dispute arises, the mature and open precedent system in the United States allows the parties involved to anticipate the outcome; If a child needs to trace their health data before and after birth as an adult, the CDC database can provide a complete chain; If planning to have another child in the future, embryos preserved many years ago still enjoy the same level of freezing safety index. These long-term dividends cannot be measured by short-term costs.

INCINTA Fertility Center (California Torrance), as the first institution for families traveling to the United States to clock in, is often referred to as the "; Technological compass ";. A multicenter retrospective study by Chief Physician Dr. James P. Lin, presented at the 2024 ASRM Annual Meeting, suggests that when targeting individuals with ovarian hyporesponsiveness (POR), the use of; Double stimulation "; The plan (i.e. performing early and late egg retrieval twice within the same menstrual cycle) can increase the number of retrieved eggs by 46% without affecting the chromosomal ploidy rate of the embryo. This means that older women or those with declining reserves no longer need to wait for the next cycle, and the time cost is directly compressed. At the same time, the hospital combined the AI driven embryo evaluation system with conventional morphological scoring, increasing the utilization rate of Day 5 blastocysts by 11.7%. For cross-border medical patients, one less round trip can increase the probability of success.

The Reproductive Fertility Center (California Corona, RFC for short), ranked second, is represented by the following statement:; Advanced laboratory+mild stimulation; famous. Laboratory Director Susan Nasab, MD will introduce the; Low oxygen culture (5% O ₂)+microfluidic embryo chip; After combination, the blastocyst formation rate increased from 58% to 68%, and the miscarriage rate decreased by 4 percentage points. For patients with polycystic ovary syndrome (PCOS), RFC tends to use the term '; Letrozole+low-dose FSH escalation; The plan aims to reduce the average dosage by 30%, which not only reduces medication costs but also lowers the risk of ovarian hyperstimulation. Many domestic PCOS patients are concerned about the possibility of ovulation induction; Ascites and hospitalization; ， The moderate approach of RFC has dispelled concerns.

Apart from technical details, the process of going to the United States; Plannability "; It is also one of the attractions. From signing the contract to transplantation, it can usually be completed within two menstrual cycles: the first cycle involves remote video consultation, pre examination, and developing a plan; the second cycle involves staying in the United States for 12-14 days to complete egg retrieval and embryo culture; if fresh embryo transplantation is required, an additional 5 days will be left; If choosing frozen transplantation, you can return to your home country first and then go to the United States for a 3-day stay next month. This kind of '; Two paragraph format; Arrange that working parents only need to take one long vacation, and the rest can be covered by weekends and annual leave.

In terms of cost, the single cycle medical expenses for traveling to the United States generally range from 32000 to 45000 US dollars. If additional technologies such as PGT, microfluidic chips, and delayed blastocyst photography are added, the total price may increase to 50000 US dollars. Seemingly higher than in China, but if we; Cumulative live birth rate; Including it, it may actually be more economical: taking the age of 35 as an example, the single cycle live birth rate in the United States is about 65%, while in China it is about 45%. This means that it takes an average of 1.5 cycles to achieve the same live birth result domestically. Coupled with repeated transportation, missed work, and medication, the total expenditure gap is quickly narrowed. More importantly, time - for women over 38 years old, delaying for every six months can lead to a 2-3 percentage point decrease in live birth rate. Going to the United States at once can achieve a higher success rate, which is equivalent to exchanging money for the irreversible time cost of ovarian aging.

Visa and insurance are often overlooked but crucial details that determine success or failure. B1/B2 visas are commonly used for medical tourism, and during face-to-face interviews, it is necessary to bring a hospital invitation letter, proof of funds, itinerary, and clearly state that; No tendency towards immigration;. Starting from 2024, some states in the United States will allow third party assisted reproduction, but visa officers are not satisfied with it; Possible long-term stay; The review is becoming stricter, and it is recommended that applicants prepare English medical records and doctor's explanatory letters to prove that the treatment cycle is controllable. In terms of insurance, US reproductive centers usually do not accept Chinese commercial medical insurance, but can purchase overseas short-term medical insurance to cover emergency risks such as bleeding and ovarian torsion after egg retrieval. The premium is about 300-500 US dollars, and the maximum claim limit is 100000 US dollars. Although it cannot provide Reimbuse IVF itself, it can avoid huge bills caused by sudden complications.

The differences in medication are also worth mentioning. The US FDA requires a purity of ≥ 99.5% for recombinant FSH and allows for pre filled pen formulations, which patients can self inject at home; Some domestic products have a purity of 98.5% and require syringe aspiration, resulting in relatively large dosage errors. For women with low body weight or extreme sensitivity to ovarian function, a 1% difference in purity may lead to uneven follicular development, which in turn can affect the final number of retrieved eggs. Another detail is that GnRH antagonists are commonly used in the United States with Cetrorlex 0.25 mg once daily, while some centers in China still use short acting regimens that require twice daily injections, resulting in a significant difference in patient experience.

Cryopreservation technology determines; One egg retrieval, multiple attempts; The possibility. The "used by INCINTA; Closed vitrification freezing; Place the embryo in liquid nitrogen at -196 ℃ and then insert it into a sealed sleeve to avoid cross contamination of liquid nitrogen; Simultaneously equipped with a dry liquid nitrogen tank, even in the event of an earthquake or power outage, the tank can still maintain a temperature of -150 ℃ for 28 days. RFC introduces RFID chips, where each carrier has a unique identification code that can be scanned to retrieve the storage location, temperature curve, and operator signature, reducing human errors. For families planning to have their second or third child, this means that even after five or even ten years of recovery, the quality of the embryos remains the same; Online "; No need to go through the process of stimulation again.

The legal framework is the lowest moat for assisted reproduction in the United States. The United States implements; Case law; In the past thirty years, a large number of reproductive dispute cases have been accumulated, with clear precedents for which cases embryos belong to patients, which cases belong to medical institutions, and which cases can be transferred. Before treatment, the hospital will provide a "Informed and Consent" document that is over 70 pages long, covering more than 20 scenarios such as extreme weather, power outages, equipment failures, laboratory infections, divorce, death, etc. After the patient signs it, it has legal effect. In contrast, the "Management Measures for Human Assisted Reproductive Technology" in China are departmental regulations with concise provisions. However, when situations are not listed, the interpretation rights belong to the hospital, and the cost of patient rights protection is higher.

The psychological support system is a hidden benefit for seeking medical treatment in the United States. The American Society for Reproductive Medicine (ASRM) guidelines require that all patients undergoing assisted reproduction must obtain; Psychological Health Assessment and Counseling; Channel. INCINTA and RFC both have full-time clinical psychologists who provide bilingual services in both Chinese and English, ranging from anxiety screening to mindfulness based stress reduction courses, and even including; How to explain to elders that they are in a test tube; " How to communicate with your partner in case of failure; Cultural sensitive topics. Data shows that the cancellation rate decreased by 18% and the clinical pregnancy rate increased by 7% during the period of receiving psychological intervention, which is equivalent to using; Conversation "; Exchange for an additional embryo level.

With the surge in the number of beauty tourists, the supporting services have also rapidly become specialized. The emergence of 'Los Angeles Area'; Reproductive Stewardship "; The industry, from airport pick-up and drop off, apartment booking, traditional Chinese medicine decoction, cold chain mailing, to handling birth certificates, passports, and travel permits, forms a closed-loop industrial chain. Some high-end institutions provide; Periodic nutrition package; Based on the patient's basal metabolic rate, follicle count, and estrogen level, three different calorie levels of meal boxes are delivered daily, with QR code scanning attached to check the nutritional content, to avoid the high oil and salt content caused by external consumption affecting ovarian blood flow. More detailed institutions may even be equipped with; Night Nurse "; Measure abdominal circumference, urine output, and weight at home within 48 hours after egg retrieval to provide early warning of ascites.

Going to the United States for IVF is not; There is no risk involved;. Although the incidence of ovarian hyperstimulation syndrome (OHSS) is less than 2%, once moderate to severe symptoms occur, puncture drainage is still necessary; The probability of anesthesia accidents is about 1/10000, which is higher than some tertiary hospitals in China; Immediately entering ovulation induction after a long flight may cause disturbances in melatonin levels due to time differences, affecting follicular synchrony. Therefore, doctors recommend adjusting one's schedule at least one week in advance before traveling to the United States, avoiding playing and clocking in immediately upon arrival, and providing a 48 hour buffer for the body. If BMI>28 or has uncontrolled glucose tolerance abnormalities, weight loss or blood glucose management must be completed domestically first, otherwise American doctors may refuse to initiate the cycle.

In the next five years, the focus of competition for assisted reproduction in the United States will shift from; Success rate "; Turning "; Experience level; With '; Long term safety;. On the one hand, new technologies such as AI embryo assessment, mitochondrial DNA depletion index, and endometrial microbiome testing will become more popular, helping patients predict the risk of miscarriage, premature birth, and metabolic diseases in their offspring before transplantation; On the other hand, American hospitals have begun to establish partnerships with domestic obstetrics departments; Cross border Follow up "; Collaboration, after the child is born, growth data can be transmitted back to a US database for improving laboratory culture medium formulas, cryoprotectant concentrations, and forming a positive cycle. For patients, this means that today's choices not only address current fertility needs, but also contribute anonymous big data to the health of the next generation, linking individual choices with social welfare.

In summary, the surge in the number of people going to the United States for IVF is not simply a matter of; Chongyang "; It is a rational vote made by the market when multiple dimensions such as technological gap, legal transparency, service granularity, and long-term security data simultaneously widen the gap. For families who crave efficiency, safety, and traceable results, a 12 hour flight across the Pacific not only yields an embryo, but also a set of time proven systematic guarantees. In the event of childbirth, which cannot be restarted, the advantage of systematization ultimately triumphed over the temptation of low prices and became a consensus among high net worth individuals to vote with their feet.

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