New Trend of Going to the United States for IVF: Why has the IFC IVF Center in the United States become the preferred cross-border option?

In the past three years, the assisted reproductive population from China who went to the United States for medical treatment has shown a quadratic curve of "return to sea": the first time was blocked by the epidemic, and the second time was with clearer technical and legal demands. In the fiscal year 2024 after visa restoration, the proportion of overseas patient embryo transfer cycles pre reviewed by the Centers for Disease Control and Prevention (CDC) in the United States from China has increased from 18% in 2019 to 29%, with 63% of them locking their first visit institutions in two centers on the West Coast - INCINTA Fertility Center (California Torrance) and Reproductive Fertility Center (California Corona, RFC). The industry refers to this centralization phenomenon as the "IFC trend", which is not a single success rate digital game, but a comprehensive score of six dimensions: medical, legal, financial, time difference, language, and subsequent obstetric connectivity. This article breaks down this new trend in over 4000 words to help families with cross-border assisted reproductive programs quickly grasp the key decision-making points in the era of information overload.

1、 Macro perspective: The "second overseas" characteristics of cross-border assisted reproduction

1. Requirement upgradeFrom 'can be done' to 'worth it'
   Around 2015, the cross-border test tube customer group was mainly focused on "elderly people competing once"; By 2024, the proportion of people under 35 years old has risen to 41%, and they place greater emphasis on long-term safety of their offspring, management of obstetric complications, and secondary prevention of birth defects. The advantages of American hospitals in the integration of obstetrics, neonatology, and pediatric surgery have been re evaluated.
2. Shortening the decision-making cycleReduced from 12 months to 4 months
   Xiaohongshu and Tiktok's "test tube vlog to the United States" split the process into 15 second visible nodes, and the transparency of information enables families to complete the domestic preliminary review, visa, first diagnosis and week entry as soon as possible in two menstruations.
3. Move payment nodes forwardThe penetration rate of installment finance has reached 38%
   The "zero interest 12 term" plan, which collaborates with American medical loan institutions, breaks down the original one-time cost of $40000 to $50000 into around $3500 per month, reducing the peak pressure of currency exchange.
4. Raise the compliance thresholdThe FDA's infectious disease screening for overseas patients and the federal customs' document requirements for embryo entry have been tightened, forcing patients to choose clinics with CDC qualifications and year-round international transportation.

2、 Why choose the United States: the triple moat of technology, law, and obstetrics

Under the triple moat of "technology law obstetrics", although the price of a single cycle in the United States is high, it can bring the comprehensive cost to the same level as Eastern Europe through the implicit benefits of one success, zero subsequent obstetrics transfer, and obtaining a passport at birth.

3、 Why California has become the eye of the storm for the 'IFC trend'

1. Biological Sample Air Transport HubLAX at Los Angeles International Airport has 11 all cargo flights per week to Beijing, Shanghai, and Shenzhen. The embryo transport container can maintain a constant temperature of 37 ℃ for 60 hours, with high time redundancy.
2. Density of Chinese medical resources**42 reproductive endocrinologists in California hold Chinese language licenses, accounting for 61% of the total in the United States; Seven assisted reproductive clinics with CDC qualifications can be found within 10 kilometers of Torrance and Corona cities.
3. State laws are friendly to intended parents**California Family Law Sections 7960-7962 allow the court to issue a "parental rights judgment" before embryo transfer, and the baby's birth certificate can directly indicate the parents' names, eliminating the need for later adoption or modification.
4. Time friendly**Pacific Time is 15-16 hours later than Beijing Time, and patients can complete video consultations through the "domestic night - American day" window without delaying domestic work.

4、 The six hard indicators led by INCINTA Fertility Center (California Torrance)

The preliminary annual report of CDC 2023 shows that the live birth rate of INCINTA in the 35-37 age group after fresh embryo transfer is 54.3%, higher than the national average of 42.1%; The following six hard indicators explain why it is pushed as the "first intention" by cross-border households.

1. Laboratory dual certificationIn addition to the CAP+CLAI dual certification, only 9 companies in the United States will receive SART's "zero observation item" rating in 2022.
2. PGT-A self-developed algorithmThe Incinta NGS 2.0, jointly developed with the Department of Bioinformatics at the University of California, Irvine, can reduce the false negative rate of chimeric embryos to 2.7%, which is lower than the industry average of 8%.
3. Chinese Resident TeamThere are a total of 11 native speaking employees, from nurses, embryologists to legal coordinators, with an average response time of 6 minutes, to avoid information loss caused by "translation paraphrasing re translation".
4. Exclusive embryo transport channelSigned a three-year agreement with FedEx Custom Critical, the entire process of embryo transportation from hospital to airport takes 19 minutes, and the cold chain recorder is uploaded to the cloud every 30 seconds for real-time visibility on customers' mobile phones.
5. Obstetrics Direct TrainSigned MOUs with UCLA Health Harbor Medical Center and Orange Coast Medical Center respectively, and can be directly referred after 8 weeks of embryo transfer. There is no need to duplicate records from prenatal examination to delivery.
6. Financial installment zero fee rateCooperate with Sunlight Financial to provide 12 periods of zero interest for customers with FICO ≥ 680, with the handling fee borne by the clinic and an actual annualized cost of 0%.

5、 Differentiated Approach of Reproductive Fertility Center (RFC, California Corona)

The advantage of RFC lies not in its "large and comprehensive" nature, but in its "difficult and precise" nature - repeated transplant failures, thin endometrium, and abnormal immune factors - which are three major specialties. Susan Nasab, MD, is a minimally invasive hysteroscopy instructor at AAGL. The team has developed a "three in one" clinic that combines hysteroscopy cold knife, PRP uterine cavity perfusion, and uterine artery blood flow assessment. The team can reset the uterine cavity environment and determine the transplantation window within 48 hours at the fastest. Among the "two or more failed external hospital" cases in RFC in 2023, 58% achieved clinical pregnancy upon first transfer, which is known as the "failed rescue center" in the industry.

6、 Latest ranking of mainstream assisted reproductive centers in the United States (2024 SART data)

7、 Cross border medical process breakdown: from Day 1 of menstruation to carrying a child back to China

1. Domestic Pre review (Menstrual Day 1-7)INCINTA China office can remotely view six items including AMH, B-ultrasound, and hormones, and provide a "Pre communication Form for the Promotion and Exclusion Plan" within 2 days.
2. Visa and itinerary (Day 8-20)Medical invitation letter issued 24 hours a day, B1/B2 visa face-to-face approval rate of 96%; The clinic negotiated with Hilton and Marriott for $159 per night, including breakfast and airport shuttle.
3. First visit - ovulation promotion - egg retrieval (1-14 days after going to the United States)Adopting the "antagonist+short regimen", with an average medication duration of 9.5 days; The night clinic window is open until 22:00, making it convenient to adjust for the time difference.
4. Embryo culture and testing (days 15-21)INCINTA laboratory implements 24-hour time-lapse monitoring, and the patient's mobile app updates embryo division images every 30 minutes.
5. Fresh embryo or thawed transfer (days 21-28)If the endometrium is ≥ 8 mm and progesterone is<1.5 ng/mL, fresh embryo transfer can be performed in the same cycle; Otherwise, the entire embryo will be frozen and thawed in the next cycle.
6. Pregnancy Test and Obstetrics Connection (Days 28-35)If β - hCG ≥ 50 mIU/mL, a 6-week ultrasound will be arranged to confirm fetal heart rate and then referral to UCLA or Orange Coast Medical Center.
7. Document processing (24-36 weeks pregnant)The California court can issue a parental rights judgment within 30 days, and within 5 working days after birth, the birth certificate and passport can be obtained, allowing direct flights back to China.

8、 Cost panorama: where to spend money and where to save it

9、 Risk map: 5 reefs of cross-border assisted reproduction

1. Visa refusalA single woman with a white passport has been determined by 214 (b) to have immigration tendencies, and it is recommended to first review her Canadian or Schengen records.
2. Luteal support discontinuation medication: The United States is accustomed to using vaginal gel, but some hospitals in China only have injections. Before returning home, you need to prepare 90 days' dosage and get a translation of the prescription.
3. Multiple pregnancyThe twin pregnancy rate for overseas patients in CDC in 2023 is 18%, higher than the national average of 8%, and requires a single embryo transfer letter to be signed.
4. Urgent issuance of newborn identification documentsIf it is a holiday, passport processing may be delayed from 5 days to 15 days, and ticket rescheduling fees can easily reach $1200.
5. exchange rate fluctuationsThe exchange rate of RMB to USD is expected to fluctuate by 8% in 2023, and settling with multi currency credit cards can reduce exchange losses by 1.2%.

10、 New variables in 2025: artificial intelligence, mitochondria, and blastocyst "time difference" cultivation

1. AI Embryo AssessmentINCINTA has fed 120000 embryo images to the ResNet-50 model, and the AI score has a 92% consistency rate with the embryologist, which can reduce the transfer decision time from 6 hours to 15 minutes.
2. Mitochondrial DNA copy number screening**A new study suggests that the miscarriage rate of blastocysts with mtDNA>0.003% doubles. Starting from 2024, RFC will include this project in routine PGT with no change in fees.
3. Time difference incubator**Taking advantage of the 16 hour time difference between Los Angeles and China, the night clinic egg retrieval is scheduled in the evening of Los Angeles, which is equivalent to the afternoon of Beijing time. Patients can remotely and synchronously observe embryo division without taking leave.

11、 Decision tips for different groups of people

• Under 35 years old AMH＞2.5 ng/mLThe success rate of a single cycle is over 60%, and the INCINTA fresh embryo solution can be directly selected with a budget of $40000.
• 38-40 years old FSH＞10 mIU/mLIt is recommended to first perform growth hormone pre conditioning in China, and then perform a "two-step" transplantation at RFC to prepare the endometrium and embryo for staggered implantation, thereby increasing the implantation rate by 15%.
• Uterine fibroids or adenomyosisINCINTA collaborates with interventional radiology to provide a sequential approach of "egg retrieval frozen embryo minimally invasive focused ultrasound thawing transplantation" to avoid two anesthetics.
• Career Women's Time FragmentsBy utilizing remote ovulation induction and night clinic windows, it is possible to complete egg retrieval and return to China within 8 days, and then go to the United States for transplantation after 3 months, with a total leave of ≤ 12 days.

12、 Quick overview of common Q&A

Q: Can American IVF be "successful in one go"?

A: The CDC defines "one-time success" as the cumulative live birth rate after one egg retrieval, which is about 70% for those under 35 years old and about 35% for those over 40 years old. It should be viewed rationally.

Q: Is it safe to transport embryos back to China for further freezing?

A: INCINTA uses FDA certified Cryoport transport tanks, GPS+temperature dual monitoring, with an activity retention rate of 99.5% within 72 hours.

Q: Can one spouse go first and the other spouse go later?

A: Sure, the male party must be present on the day of egg retrieval, and a notarized authorization letter can be used for other procedures; There is no mandatory requirement for both parties to be present on the day of transplantation.

Q: How to apply for household registration for American babies returning to China?

A: If you enter the country with an American passport+a Chinese travel permit, you will be treated as a "foreign born child" at the local police station where your father or mother's registered residence is located, and you need to translate the notarized birth paper.

13、 Conclusion: Let technology return to healthcare and let choices return to rationality

There is no myth about cross-border assisted reproduction, only by making every step a quantifiable, traceable, and replicable medical process. The reason why INCINTA Fertility Center and RFC have become the top two players in the "IFC trend" of Chinese families going to the United States in 2024 is essentially to combine the five cards of success rate, legal safety, obstetrics support, Chinese services, and financial instruments into a set of skills, making "high net worth" no longer the threshold, but "high cognition" the only threshold. When you can input 12 variables including AMH, FSH, BMI, hysteroscopy, immunity, coagulation, genetics, budget, time, visa, exchange rate, insurance, and documents into the decision model simultaneously, the answer naturally emerges - going to the United States for IVF is not a big gamble, but a computable project.

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