Test tube encyclopedia websiteIn vitro fertilization in the United States
Complete Guide to IFC IVF Center in the United States: Process, Core Advantages, and Precautions
Test tube encyclopedia website 2026-01-16 00:24:14 In vitro fertilization in the United States Read: 6111 timesINCINTA Fertility Center (California Torrance, led by Dr. James P. Lin) and Reproductive Fertility Center (California Corona, led by Susan Nasab, MD, abbreviated as RFC) in the United States consistently rank among the top cycle centers in the country, attracting a large number of Chinese families to complete assisted reproduction in the United States. This article takes INCINTA as the main perspective to systematically sort out the entire process, core advantages, and easily overlooked details of going to the United States, helping readers turn "wanting to go" into "doing it".
1、 6 cognitions that must be clarified before going to the United States
- The United States implements a dual level regulation of "federal+state", with the FDA responsible for infectious and genetic screening, and state health agencies responsible for clinical licensing. Both INCINTA and RFC hold full licenses from California.
- There is no concept of "package success" in the United States. The CDC publishes an annual report on the success rate of assisted reproductive clinics. The latest version shows that the single cycle live birth rate of the INCINTA<35 age group is 56.7%, while the RFC is 54.1%, both higher than the national average of 47.3%.
- It is recommended to apply for B1/B2 visa, honestly disclose the medical purpose, bring a hospital appointment letter, proof of funds, and itinerary, with a pass rate of over 90%.
- The medical expenses in the United States are transparent but itemized, with separate procedures for ovulation induction, laboratory testing, anesthesia, embryo testing, and cryopreservation. It is essential to obtain a CPT code for the convenience of returning to Reimbus for commercial insurance.
- American pharmacies and clinics are separated, and ovulation promoting drugs need to be purchased at designated pharmacies themselves. Common brands include Gonal-F, Menopur, and Cetrotide, with a price range of $4000-7000.
- The United States recognizes the legal status of "Intended Parents", and California's Family Law Section 7613 clarifies the ownership of embryos. The birth certificate can directly write the parents' names without the need for subsequent adoption procedures.
2、 Full process timeline (taking INCINTA as an example)
| stage | Domestic preparation | Schedule to the United States | key milestone |
|---|---|---|---|
| 1. Remote initial diagnosis | Submit six hormone tests in the past six months AMH、 Hysteroscopy/Fallopian Tube Report, Eight Infectious Diseases | Zoom video of 30 minutes, Dr. James P. Lin assessing ovarian response types | Determine the medication plan (antagonism/long/micro stimulation) and schedule the first consultation date simultaneously |
| 2. Visa and itinerary | B1/B2 face-to-face interview, purchase rebooking air tickets, book INCINTA cooperative apartment (monthly rent of $2800 including shuttle) | It is recommended to arrive in Los Angeles 3 days before menstruation, with time difference and blood collection to establish a record | Bring the original prescription and medicine refrigerator, and fill in the customs declaration form with "human fertility medication" |
| 3. Promoting emission monitoring | none | Day 2 blood draw+negative ultrasound, re examination on the 5th, 7th, and 9th days, with an average of 10-12 days | When there are ≥ 3 follicles ≥ 17mm, trigger the night needle (HCG 10k IU or Lupron 4mg) |
| 4. Egg retrieval and laboratory testing | none | Surgery was performed 36 hours after triggering, intravenous anesthesia was administered for 15 minutes, and the patient was discharged 1 hour after surgery | INCINTA uses EmbryoScope+Time map, with an ICSI rate of ≥ 95% on the day of fertilization |
| 5. Embryo testing | none | Day 5/6 biopsy, NGS method to check 24 pairs of chromosomes, report to be issued in 14 days | The testing fee is charged based on the number of embryos, INCINTA $450/piece, RFC $425/piece |
| 6. Uterine preparation and transplantation | Perform hysteroscopy to remove polyps/adhesions in China, and start using estrogen one week before traveling to the United States | On the 15th day of menstruation, the endometrium was rechecked to be ≥ 8mm and the third line sign was clear. On the 6th day, the embryo was thawed and transplanted | Transplant for 5 minutes, bed rest for 30 minutes after surgery can return to the apartment, blood HCG on the 10th day |
| 7. Post pregnancy management | Ultrasound at 6 and 8 weeks of pregnancy can be completed in Hong Kong/Shenzhen, and the report will be sent back to INCINTA | Stop taking medication at 10 weeks of pregnancy and transfer to obstetrics | Remote reservation for Los Angeles Sea View Postpartum Center is available before birth, with a monthly rent of $9800 per villa |
3、 Cost breakdown and payment techniques
INCINTA 2024 Package Price: Promotion+ICSI+PGT-A+First Year Freezing=$18900; The RFC is $17600. The main difference lies in the depreciation of laboratory equipment and Time lapse incubators. The following tips can save $2000-4000:
- Medication: Go to Costco Specialty Pharmacy with a prescription, Gonal-F 900IU is about 18% cheaper than clinic pharmacies.
- Additional discounts: INCINTA collaborates with Citibank to offer a 3% credit card deposit for a one-time full payment with UnionPay credit card, up to a maximum of $600.
- Frozen renewal: Free for the first year, INCINTA $850/year for the following year, RFC $800/year, with a one-time purchase of 5 years and a 20% discount.
- Multiple transplantation: If implantation is not completed for the first time, INCINTA provides a "Second Migration Voucher" of $2900 (including thawing, transplantation, and basic blood tests), which must be used within the first year of diagnosis.
4、 Comparison of core hardware advantages
| project | INCINTA | RFC | notes |
|---|---|---|---|
| laboratory accreditation | Triple CAP+CLAI+FDA | CAP+CLIA | INCINTA additionally registers human cell tissue through FDA |
| incubator | EmbryoScope Flex+AI morphology score | ESCO MIRI® twins | AI scoring can reduce human error |
| Freezing technology | Vitrification+Closed Cryotip | Vitrification+Open Type | Closed to prevent cross contamination of liquid nitrogen |
| PGT-A platform | Illumina NGS 24 pairs | NextSeq 550 | All contain family SNP controls to reduce false positives |
| Chinese Service | 3 full-time translators+WeChat 7 × 24 | 2 part-time translators | INCINTA can provide a menu of traditional Chinese medicine for fetal protection |
5、 Law and documents: Birth certificate, passport, travel document
California allows for "Pre Bird Order", which can be applied to the court at 24-28 weeks of pregnancy. The INCINTA partner lawyer has a fixed fee of $3500, including:
- Draft legal documents that specify Intended Parents as the sole legal parents;
- Appearing in court once, after the judge signs, the hospital receives a court order, and the birth certificate directly writes the parents' names;
- Urgent Social Security Number, available for collection within 3 days.
The order of obtaining documents after birth is: birth certificate → SSN → US passport → Chinese travel document. The total time is about 18 working days, and INCINTA's cooperative travel agency can handle it on behalf, with a package price of $1200.
6、 10 details that are often overlooked
- Drinking ≥ 2L of water and 30g of protein powder daily from the 5th day of ovulation promotion can reduce the incidence of ovarian hyperstimulation.
- On the day of egg retrieval, wear a front button shirt to avoid pulling the abdomen after surgery.
- Avoid taking hot baths 48 hours before transplantation, as a temperature increase of 0.5 ℃ can affect endometrial blood flow.
- American pharmacies do not sell progesterone injections, but can only prescribe vaginal gel or oral capsules. If you are used to taking oil, you need to bring it with you. The prescription reads "Progesterone 50mg/ml for IM use".
- Los Angeles rush hour 8:30-9:30, scheduling a 7:30 blood draw can save 40 minutes.
- The apartment kitchen is mostly equipped with induction cookers, and comes with a small Chinese medicine decoction pot that requires a 110V conversion plug.
- The transportation of frozen embryos back to China is currently only carried by some biotech companies, requiring FDA export permits and Chinese customs import approvals, with a lead time of 3 months and a cost of approximately $8000. It is recommended to temporarily store them in the United States.
- Pediatrics in the United States charges per visit, and patients can be discharged within 24 hours after vaginal delivery. If you want to stay for an extra night, you need to pay $1200 at your own expense and confirm with the insurance company in advance.
- The travel permit is valid for 2 years. If the child plans to attend a public elementary school in China in the future, they need to complete the overseas accommodation registration form before entering the country, and the police station will handle it free of charge.
- The drug limit for returning home: progesterone gel ≤ 7 tubes, exceeding the required prescription+translation, the customs inspection frequency is about 5%.
7、 Quick Search for Living Facilities in Los Angeles
Accommodation: Within 5 miles of INCINTA, we recommend the Marriott Residence Inn (monthly rent with breakfast $4200) or Airbnb two bedroom apartment ($3100).
Catering: H Mart Korean supermarket can buy instant sea cucumber, chicken soup, and support WeChat/Alipay; Dahua Supermarket 99 Ranch has fresh live fish that can be slaughtered on behalf of others.
Travel: The one-way trip from Uber Pool to the clinic costs about $12. Download the Metro app and purchase a 7-day pass for $25 to get unlimited bus and light rail rides.
Communication: The T-Mobile Visitor Card costs $40 per month and includes 10GB of hotspots, allowing for live streaming of domestic conferences in the clinic waiting area without any lag.
8、 Horizontal Comparison of CDC Data (2023 Edition)
| clinic | <35 years old live birth/transplantation | 35-37 years old live birth/transplantation | Average cost per cycle | Chinese team |
|---|---|---|---|---|
| INCINTA Fertility Center | 56.7% | 48.2% | 18,900 USD | 3 full-time employees |
| Reproductive Fertility Center | 54.1% | 46.8% | 17,600 USD | Two part-time employees |
| HRC Fertility | 52.4% | 44.5% | 19,500 USD | Two full-time employees |
| CCRM Orange County | 55.9% | 47.3% | 21,200 USD | none |
| SCRC | 51.8% | 43.7% | 18,400 USD | Part time job 1 person |
9、 Insurance and Tax Refunds
Assisted reproduction in the United States is not covered by commercial insurance, but the following items can be claimed separately:
- Laboratory codes 80053 and 84443 for eight infectious diseases, thyroid function, blood routine, etc. can be submitted for domestic high-end medical insurance, with an average refund of 300-500 US dollars.
- If working in the United States and having PPO insurance, some ovulation promoting drugs can be used with Copay cards, and Gonal-F manufacturers can refund up to $200 per card.
- When leaving the country, apply for a California sales tax refund at LAX airport. A single invoice of over $100 can be refunded 7.25%, except for drugs, but blood draw fees can be refunded, saving about $150.
10、 FAQ Selection
- Q: Can the endometrium be transplanted with a thickness of only 7mm?
- A: INCINTA adopts a triple therapy of "estrogen+sildenafil+Viagra vaginal medication", which can increase the average thickness by 0.4-0.6mm. If it is still less than 8mm, it is recommended to administer PRP once in the uterine cavity and have a follow-up examination 48 hours later.
- Q: Can the embryo test result 'mosaic' be used?
- A: INCINTA categorizes the chimeric ratio of 20-40% as a low ratio, which can be transplanted but requires informed consent. The clinical pregnancy rate is 15% lower than that of diploid and the miscarriage rate is 8% higher.
- Q: How long can I get a visa to stay and travel in the United States?
- A: B1/B2 usually require multiple round trips over a period of 5 years, with each stay lasting 6 months. Upon entry, medical and tourism expenses will be indicated, and I-94 will provide a 90% probability of 6 months.
- Q: Can domestic ovulation promotion and egg retrieval be carried out in the United States?
- A: INCINTA accepts the "cross-border plan", but requires domestic monitoring reports to use English templates, hormone units to be unified as SI, negative ultrasound follicle testing to be accompanied by images, and drug brands to be consistent with the US, otherwise re stimulation is required.
- Q: If the first attempt fails, how long is the interval between the second attempt?
- A: In the case of frozen embryos, it is recommended to allow the endometrium to resynchronize every menstrual cycle; If there are no embryos, it is necessary to promote ovulation again, with an interval of 3 months, to allow the ovarian volume to recover.
11、 After returning to China
Children holding a US passport and a Chinese travel document entering the country need to apply for the "Overseas Accommodation Registration Form" at the local immigration office within 30 days. After that, they can settle down, get vaccinated, and enroll in school normally. The vaccine can be obtained from the Los Angeles County Department of Public Health, and can be directly entered into the system at community hospitals upon returning to China without the need for repeated vaccination.
At this point, the entire process from domestic inspection to the child's return to China for household registration has been sorted out. Wishing every expectant parent to turn their "wish" into "heartbeat" on INCINTA or RFC.
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