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The application of PGT technology in test tube in the United States and the differences in China

Test tube encyclopedia website 2025-09-28 06:19:11 American test tube Read: 7964 times

Of course, the following is aboutApplication of PGT technology (pre implantation genetic testing) in IVF in the United States, comparing with the key differences in application in Chinese Mainland, to comprehensively analyze its clinical significance, technical advantages and applicable population:

🧬 1、 What is PGT?

**PGT (Preimplantation Genetic Testing) * * is a technique for chromosomal or genetic testing of embryos prior to embryo transfer, which can be divided into three types:

type	full name	effect
PGT-A	Aneuploidy	Detecting abnormal chromosome numbers in embryos (such as Down syndrome)
PGT-M	Monogenic	Detecting monogenic genetic diseases (such as thalassemia)
PGT-SR	Structural Rearrangement	Detecting chromosomal structural rearrangements (such as balanced translocations)

II. Conventional Application of PGT in IVF in the United States

project	Conventional practice in the United States
🔬 Is it commonly used	✅ Widely used by elderly or those with a history of failure (almost standard in some clinics)
🧪 Technology Readiness Level	✅ Fifth/sixth day blastocyst biopsy+whole gene chip or NGS sequencing
📈 Relationship with success rate	✅ Significantly increase pregnancy rate and reduce miscarriage rate in elderly women
👩⚕️ Doctor's advice	Most clinics actively recommend PGT-A, especially for those aged 35 years or older or with fewer embryos
🧑🍼 embryo selection	Can clearly select embryos with normal chromosomes to avoid adverse pregnancies

🔹 For example, the INCINTA Fertility Center widely uses the PGT-A+embryo scoring system to help patients select optimal embryos.

🇨🇳🇳🇨🇳🇳🇨🇳🇨🇳🇨🇳🇨🇳🇳🇨🇳

project	Current situation of Chinese Mainland
🚫 Is it popular	❌ Not widely available, only limited to some tertiary hospitals, strict approval process
⚖️ Legal restrictions	Classified as "Class III Assisted Reproductive Technology", requiring approval and ethical review
🧪 Indicative limitations	Only for patients with a history of genetic history, recurrent miscarriage, or infertility
⏳ Periodic process	Approval and process extension by 1-2 months, with many restrictions
💬 Doctor's attitude	Non mainstream suggestion, requiring strong patient demand and compliance with indications

⚠️ Many patientsEven if it is suitable for PGT, it is difficult to implement smoothly in China。

📊 4、 Comparison of Technical Differences (US vs Domestic)

Dimension	🇺🇸 United States	Chinese Mainland
Detection method	NGS+AI assisted analysis (mainstream)	Part of it is still chip or FISH method
Embryo biopsy stage	Day 5/6 blastocyst biopsy (safer)	Some are still undergoing Day 3 embryo testing
Embryo damage rate	Extremely low, high laboratory standards	There are significant technological differences, and some hospitals have higher risks
PGT success rate improvement	✅ Improve the success rate of elderly transplantation by 20-30%	Some hospital data is not publicly available, and the actual effect is yet to be evaluated

👩🔬 5、 What demographic is PGT technology suitable for?

For the crowd	Do you recommend using PGT
Female aged ≥ 35	✅ Highly recommended
Multiple test tube failures	✅ Suggest screening embryos
Has a family history of genetic disorders	✅ Suggest doing PGT-M
Chromosomal translocation (such as balanced translocation)	✅ PGT-SR is required
There are not many embryos, hoping for success in one attempt	✅ Selecting embryos is particularly important

💰 6、 PGT Cost Comparison (2025)

region	PGT fee range	notes
🇺🇸 United States	$4000-6000 per cycle	Multiple clinics included in the package (such as PGT+multi cycle IVF)
Chinese Mainland	¥ 30000-50000 per cycle	The approval process is complex and requires additional medical report support

✅ 7、 Summary and Comparison Table

comparative dimension	🇺🇸 United States	Chinese Mainland
Is PGT widely available	✅ Yes, almost all mainstream clinics provide	❌ No, approval is required
Technology Readiness Level	✅ NGS mainstream, high security	⭕ Partially backward
Detection timing	Embryo biopsy as the main method (Day 5/6)	Embryo biopsy is the main method (Day 3 or mixed)
Legal restrictions	✅ Legitimate and flexible	❌ Strict approval, limited indications
Increased success rate	✅ Significant improvement	⭕ The effect is unclear or there is no data available
Recommended audience	Elderly/History of Failure/Families with Genetic Risk	Same as above, but difficult to implement

🧭 suggestion

If you belong to the following groups of people,Strongly recommend considering traveling to the United States and using PGT-A：

Multiple failed IVF attempts but still unable to implant
Elderly women (≥ 37 years old)
History of genetic disorders or chromosomal abnormalities (such as congenital diseases in the family)
The number of embryos is limited, but we hope for a successful pregnancy at once

If you are willing to tell me your age, duration of infertility, IVF experience, etc., I can customize one for youIs it suitable for PGT medical advice+clinic recommendation+cost estimation listDo you need it?

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