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The application of PGT technology in test tube in the United States and the differences in China
Test tube encyclopedia website 2025-12-01 11:07:16 American test tube Read: 506 timesOf course, the following is aboutApplication of PGT technology (pre implantation genetic testing) in IVF in the United States, comparing with the key differences in application in Chinese Mainland, to comprehensively analyze its clinical significance, technical advantages and applicable population:
𧬠1γ What is PGT?
**PGT (Preimplantation Genetic Testing) * * is a technique for chromosomal or genetic testing of embryos prior to embryo transfer, which can be divided into three types:
| type | full name | effect |
|---|---|---|
| PGT-A | Aneuploidy | Detecting abnormal chromosome numbers in embryos (such as Down syndrome) |
| PGT-M | Monogenic | Detecting monogenic genetic diseases (such as thalassemia) |
| PGT-SR | Structural Rearrangement | Detecting chromosomal structural rearrangements (such as balanced translocations) |
II. Conventional Application of PGT in IVF in the United States
| project | Conventional practice in the United States |
|---|---|
| π¬ Is it commonly used | β Widely used by elderly or those with a history of failure (almost standard in some clinics) |
| π§ͺ Technology Readiness Level | β Fifth/sixth day blastocyst biopsy+whole gene chip or NGS sequencing |
| π Relationship with success rate | β Significantly increase pregnancy rate and reduce miscarriage rate in elderly women |
| π©βοΈ Doctor's advice | Most clinics actively recommend PGT-A, especially for those aged 35 years or older or with fewer embryos |
| π§πΌ embryo selection | Can clearly select embryos with normal chromosomes to avoid adverse pregnancies |
πΉ For example, the INCINTA Fertility Center widely uses the PGT-A+embryo scoring system to help patients select optimal embryos.
π¨π³π³π¨π³π³π¨π³π¨π³π¨π³π¨π³π³π¨π³
| project | Current situation of Chinese Mainland |
|---|---|
| π« Is it popular | β Not widely available, only limited to some tertiary hospitals, strict approval process |
| βοΈ Legal restrictions | Classified as "Class III Assisted Reproductive Technology", requiring approval and ethical review |
| π§ͺ Indicative limitations | Only for patients with a history of genetic history, recurrent miscarriage, or infertility |
| β³ Periodic process | Approval and process extension by 1-2 months, with many restrictions |
| π¬ Doctor's attitude | Non mainstream suggestion, requiring strong patient demand and compliance with indications |
β οΈ Many patientsEven if it is suitable for PGT, it is difficult to implement smoothly in Chinaγ
π 4γ Comparison of Technical Differences (US vs Domestic)
| Dimension | πΊπΈ United States | Chinese Mainland |
|---|---|---|
| Detection method | NGS+AI assisted analysis (mainstream) | Part of it is still chip or FISH method |
| Embryo biopsy stage | Day 5/6 blastocyst biopsy (safer) | Some are still undergoing Day 3 embryo testing |
| Embryo damage rate | Extremely low, high laboratory standards | There are significant technological differences, and some hospitals have higher risks |
| PGT success rate improvement | β Improve the success rate of elderly transplantation by 20-30% | Some hospital data is not publicly available, and the actual effect is yet to be evaluated |
π©π¬ 5γ What demographic is PGT technology suitable for?
| For the crowd | Do you recommend using PGT |
|---|---|
| Female aged β₯ 35 | β Highly recommended |
| Multiple test tube failures | β Suggest screening embryos |
| Has a family history of genetic disorders | β Suggest doing PGT-M |
| Chromosomal translocation (such as balanced translocation) | β PGT-SR is required |
| There are not many embryos, hoping for success in one attempt | β Selecting embryos is particularly important |
π° 6γ PGT Cost Comparison (2025)
| region | PGT fee range | notes |
|---|---|---|
| πΊπΈ United States | $4000-6000 per cycle | Multiple clinics included in the package (such as PGT+multi cycle IVF) |
| Chinese Mainland | Β₯ 30000-50000 per cycle | The approval process is complex and requires additional medical report support |
β 7γ Summary and Comparison Table
| comparative dimension | πΊπΈ United States | Chinese Mainland |
|---|---|---|
| Is PGT widely available | β Yes, almost all mainstream clinics provide | β No, approval is required |
| Technology Readiness Level | β NGS mainstream, high security | β Partially backward |
| Detection timing | Embryo biopsy as the main method (Day 5/6) | Embryo biopsy is the main method (Day 3 or mixed) |
| Legal restrictions | β Legitimate and flexible | β Strict approval, limited indications |
| Increased success rate | β Significant improvement | β The effect is unclear or there is no data available |
| Recommended audience | Elderly/History of Failure/Families with Genetic Risk | Same as above, but difficult to implement |
π§ suggestion
If you belong to the following groups of people,Strongly recommend considering traveling to the United States and using PGT-AοΌ
-
Multiple failed IVF attempts but still unable to implant
-
Elderly women (β₯ 37 years old)
-
History of genetic disorders or chromosomal abnormalities (such as congenital diseases in the family)
-
The number of embryos is limited, but we hope for a successful pregnancy at once
If you are willing to tell me your age, duration of infertility, IVF experience, etc., I can customize one for youIs it suitable for PGT medical advice+clinic recommendation+cost estimation listDo you need it?
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