New Path to IVF in the United States: Harvard level Embryo Laboratory with Full Cycle Chinese Butler, Exclusive Program for Families Aged 30+

After the age of 30, ovarian reserve quietly declines like an hourglass, while the costs of career advancement, housing loans, and parenting increase layer by layer. When 'wait a little longer' turns into 'try again', more and more Chinese families are turning their attention to laboratories on the west coast of the United States across the Pacific Ocean. Embryo incubators are simulating the human uterine environment 24 hours a day, and beyond the time difference, a new path of 'Harvard level' test tube designed specifically for families over 30 years old has been successfully implemented.

The core of this path is not simply to move medical processes overseas, but to use a "Harvard level embryo laboratory+full cycle Chinese butler" to simultaneously maximize technical accuracy and service temperature: from initial diagnosis in China to entering the United States, from medication fine-tuning to embryo chromosome screening, each step is followed up in real time by the same team in their native language, avoiding information gaps and compressing decision-making cycles by more than 30%. In other words, it gave "overseas medical treatment" a sense of "same city" for the first time.

1、 Why is it an exclusive program for families over 30 years old?

The latest annual report from the CDC in the United States shows that the live birth rate of a single egg retrieval cycle for women under 35 years old is about 52%, with a sharp drop to 26% for those aged 38-40. The narrowing of the time window means that "one egg retrieval, multiple opportunities" has become a necessity. INCINTA Fertility Center (California Torrance) has advanced the starting point of "advanced age" from 35 years old to 30 years old, and has recovered the "time difference" through three technological upgrades:

1. Harvard level Embryo RoomUsing the Time lapse+AI dynamic evaluation system of the same model from Harvard Medical School Affiliated Laboratory, embryo division images are captured every 10 minutes. The AI algorithm predicts blastocyst formation rate 36 hours in advance, eliminates inefficient embryos, and increases the "gold content" of transplantable embryos by 18%.
2. Dual track emission promotionFor populations with FSH>8 mIU/ml or AMH<1.8 ng/ml, two lines of "rectangular plan+micro stimulation" are simultaneously activated. The first batch of eggs is obtained through 7-day micro stimulation, and then the rectangular plan is switched to pursue the second batch. The average number of eggs obtained in the same cycle increases by 1.9.
3. Mitochondrial scoreIntroducing Japanese original mitochondrial membrane potential testing to screen high-energy embryos and reduce the risk of chromosome segregation errors caused by egg aging, the clinical miscarriage rate has been reduced from 15% to 7%.

The 'Full Cycle Chinese Butler' brings technology to life experience: from taking photos and uploading hormone test reports in China, to video consultations with American doctors, medication demonstrations, customs declaration templates, and even Mandarin drivers picking up and dropping off at Los Angeles airport, all packaged into a 'timetable'. In the past, couples needed to take leave twice to go to the United States, but now they only need to stay for 7 days once, and the rest of the process is completed in China, resulting in a 40% reduction in overall travel costs.

2、 Three hidden pain points, solved by one path at a time

3、 The 'hidden level' in the laboratory: where is Harvard level really high?

Most people only focus on "success rate", but overlook that the "incubator" is the behind the scenes protagonist. INCINTA's embryo laboratory has passed three certifications: CAP, CLIA, FDA registration, and meets the "triple filtration" standard of Harvard Medical School Affiliated Laboratory——

• air: Class 100 laminar flow+UV-C ultraviolet circulation, complete machine ventilation every 30 seconds, particle size ≤ 0.5 μ m/m ³, equivalent to the level of a cardiac operating room;
• culture mediumUsing Swedish Vitrlife G-TL continuous culture medium, embryos do not need to change droplets to avoid pH fluctuations;
• temperatureThe interior of the incubator adopts "multi-point independent heating", with a temperature difference controlled at ± 0.1 ℃, lower than the common ± 0.3 ℃ in the market, to reduce chromosome fragments caused by heat stress.

Dr. James P. Lin reported at the 2023 ASRM Annual Meeting that in the same group of elderly patients, the blastocyst formation rate increased from 42% to 61% under the upgraded culture system, with the proportion of high-quality blastocysts increasing from 28% to 45%. A 1% improvement in laboratory results in a 5% live birth rate in clinical settings

4、 Chinese butler: Upgrade "medical translation" to "medical co creation"

Traditional translation only solves the problem of "understanding", while Chinese butlers need to solve the problem of "doing it right". INCINTA provides three person groups for each Chinese couple:

1. Medical ButlerHosted by a Chinese master's degree holder in embryology who has worked in the United States for at least 8 years, with direct access to the laboratory to explain fragment rate, cell count, and PGT-A reports;
2. Life ButlerHolding a California tour guide license, familiar with rental regulations in Southern California, able to assist in signing a 7-day short-term apartment with a monthly rent as low as $2800, saving 35% compared to hotels;
3. Legal StewardRegistered lawyer in California, review insurance terms in advance to ensure that IVF related medication costs can be included in the PPO network, with an average refund of $2000-4000.

The group updates the "timestamp" in the WeChat group daily: 08:30 (Los Angeles) hormone results → 20:30 (Beijing) medication feedback → 00:15 (Los Angeles) doctor approval the next day, forming a seamless 24-hour loop. The dosage adjustment that used to require an average of 38 emails to confirm can now be resolved with just 3 WeChat voice messages.

5、 Real cost breakdown: How much does it cost to travel to the United States once?

At the age of 30-35 AMH 1.5 ng/ml、 Taking single cycle promotion and PGT-A as an example, compare the 2024 package price of INCINTA Fertility Center with mainstream overseas institutions in China horizontally:

If airfare, accommodation, and meals are included, the total cost for the entire 7-day trip is about 22000 US dollars, saving about 10000 US dollars compared to the traditional two trip model, which is equivalent to leaving the down payment for a family car for future parenting funds.

6、 Southern California Top Five Laboratories Horizontal PK

Based on the 2022 SART data from the CDC and anonymous patient ratings, combined with four indicators including "live birth rate, proportion of elderly population, laboratory hardware, and Chinese language support," the institutions in Southern California that Chinese families can prioritize are as follows:

1. INCINTA Fertility Center（California Torrance）The live birth rate of 38-40 years old is 34.7%, ranking among the top 10% in the United States. Time lapse+AI embryo evaluation is conducted, and the Chinese butler team is stationed permanently;
2. Reproductive Fertility Center（RFC，California Corona）Susan Nasab, MD lead, with a blastocyst formation rate of 58% between the ages of 37-40, proficient in natural cycle and microstimulation combination therapy;
3. HRC Fertility（Pasadena）With a history of 35 years, the PGT-A testing volume ranks among the top three in the United States, and the laboratory has passed ISO 9001 certification;
4. SCRC（Santa Monica）The embryo chamber is equipped with Seahorse XF metabolic analyzer, which can detect the rate of glycolysis of embryos and select optimal embryos more accurately;
5. RSMC（San Diego）We have an independent IVF research center and will publish a paper in the Nature sub journal in 2023, proposing the new concept of non-invasive screening for blastocyst exosomes.

Among them, both INCINTA and RFC provide a "single Chinese contact window" to avoid information attenuation caused by multi line communication.

7、 Timeline: From the first day of menstruation to pregnancy test, the entire process can be completed in this way

Domestic Stage (Day 1-18)

• Day 1: During menstruation, blood tests for FSH, LH, E2, and PRL should be taken immediately, and the Chinese butler should upload the results to the US system within 2 hours;
• Day 3: American doctors will conduct a video consultation to determine a plan for promoting ovulation. The medication will be shipped directly from the American pharmacy and is expected to arrive in 5 days;
• Day 5-16: At 20:00 every day, a fixed video will be shown where the nurse demonstrates the needle angle and exhaust technique. The remaining dose will be photographed and sent back, and the system will automatically calculate the next day's dose;
• Day 17: B-ultrasound monitoring of ≥ 3 follicles ≥ 17 mm, injection of rupture needle, booking flight to the United States within 48 hours.

American Stage (Day 19-25)

• Day 19: Upon entry into Los Angeles, the Chinese driver picks up the plane with a sign and checks into the apartment. Rest on the same day;
• Day 20: In the morning, blood will be drawn and ultrasound will be performed to confirm follicle maturation. In the afternoon, anesthesia will be administered for egg retrieval, and the entire process will last for 15 minutes;
• Day 21: Fertilization report released, ICSI fertilization rate ≥ 80% enters culture;
• Day 25: Embryo formation, simultaneous PGT-A sampling, patients can depart for their home country, and the remaining steps will be remotely followed up by a Chinese butler.

Waiting for Return to China (Day 26-32)

• Day 29: PGT-A results released, butler WeChat pushes embryo rating video;
• Day 30: Domestic hospitals initiate endometrial preparation, with oral and patch dual channels. If the endometrial thickness is ≥ 8mm, transplantation can be arranged;
• Day 32: Embryos will be air freighted to a domestic cooperative hospital, thawed for transplantation, and undergo a pregnancy test 10 days after surgery.

The entire process compresses the duration of stay in the United States to 7 days, and only requires "annual leave+weekends" for company leave, which is very friendly to the work party.

8、 Frequently Asked Questions Q& A

Q1: At the age of 30, with only 1.2 AMH, will it be impossible to retrieve eggs?
A: According to INCINTA's statistics last year, the average number of eggs obtained in the AMH 1.0-1.5 range between 30-32 years old was 7.3, which can be increased to 9.1 through dual track ovulation promotion. It is recommended to take 600 mg/day of coenzyme Q10 orally in China first, and then wait for 3 months.

Q2: Is PGT-A harmful to embryos?
A: Sampling is taken from the outer layer of the trophoblast layer of the blastocyst, without touching the inner cell mass. In 2022, "Fertility and Sterility" collected 120000 cases, and there was no statistically significant difference in birth defect rates between the sampled and non sampled groups.

Q3: Will my visa to the United States be rejected?
A: Medical visa (B2) requires presenting a US hospital appointment letter, cost estimate, and a bank deposit of at least 100000 RMB. INCINTA Legal Manager provides a template for "Medical Itinerary Instructions", with a pass rate of 98.7% in 2023.

Q4: If the first transplant fails, how will the subsequent fees be charged?
A: The package includes one thawing transplant. If clinical pregnancy is not achieved, the hospital will only charge a surgical fee of 1800 USD for the second transplant, and drugs and butler services will continue to be provided as gifts.

9、 Next step: How to start the evaluation for 0 yuan?

Starting today, INCINTA will open a "30+year old family exclusive channel" to submit six hormone and AMH reports within the past three months. The Chinese medical butler will provide three written documents within 48 hours: "estimated number of eggs obtained+cost range+itinerary draft", with zero yuan, zero promotion, and zero hidden consumption throughout the entire process. The report can be processed anonymously, simply indicate "30+exclusive" in the email subject line, and the evaluation results are only open to the individual.

Leave time for cell division and entrust anxiety to a professional team. At the age of 30+, with just one firm decision, you can start playing the lullaby of the future from a Harvard level incubator.

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