New Path to IVF in the United States: Harvard Reproductive Center's 1-on-1 Program for a More Secure Scientific Cycle

When "late childbirth" becomes a high-frequency term in first tier cities, and "repeated transplant failures" become a common sigh among the pregnancy preparation group, more and more Chinese families aged 28-45 are turning their attention to the reproductive medicine cluster on the west coast of the United States across the Pacific Ocean. Visa liberalization, flight resumption, and exchange rate friendliness make the window for assisted reproductive technology in the United States in 2024 more spacious than at any time in the past three years. But 'going' is only the first step, 'how to go', 'who to find', 'how to arrange the cycle', and 'how to control the risk' are the winning and losing hands that determine the experience and outcome. The "1-on-1 Harvard Advisor Program" launched by INCINTA Fertility Center in Torrance, California, upgrades the traditional "group assembly line" for IVF in the United States to "research grade private customization", truly returning the scientific cycle to the word "peace of mind". This article uses nearly five thousand words to break down the underlying logic, timeline, cost table, risk list, and why it is becoming the "ultimate option" for middle and high net worth families before their second transplant.

1、 Transforming 'Research Level' into 'Service Level': How Harvard Advisory Team Sinks to Clinical Practice

INCINTA Fertility Center itself is not a Harvard University affiliated hospital, but through the "Harvard Reproductive Science Advisory Committee" mechanism, it has turned the original algorithm, randomized controlled data, and endometrial receptivity model of Brigham and Women's Hospital affiliated with Harvard Medical School, as well as the one on one endometrial receptivity model just presented at the American Society for Reproductive Medicine (ASRM) annual meeting, into a practical "one-to-one" toolkit. Simply put, Dr. James P. Lin, whom the patient met at Torrance Clinic, was accompanied by a "shadow team" consisting of four Harvard postdoctoral fellows, two AI bioinformatics engineers, and one clinical pharmacology statistician. They only do two things every day: first, turn the latest global papers into executable medical orders; Secondly, inject the patient's daily hormone, ultrasound, and metabolomics data back into the model to predict the follicle curve for the next 72 hours. Does it sound like a fairy tale? It is this system that will enable INCINTA's 2023

2、 The "Four Dimensional" Decomposition of the Scientific Cycle: Time, Dose, Sequence, and Environment

1. Time: In traditional beliefs, "entering the week on the second day of menstruation" is a golden rule, but the Harvard model found that for FSH> 10. AMH 2. Dose: The starting dose of FSH is no longer a one size fits all approach based on weight steps, but is determined by real-time detection of basal antral follicle count (AFC), serum AMH, and the newly launched "follicular fluid metabolome" last year, using algorithms to derive the optimal range for individuals. The dose error is within ± 37.5 IU, and the ovarian hyperstimulation (OHSS) rate has decreased from the national average of 4.7% to 1.3%.
3. Order: Egg retrieval first or hysteroscopy first? Should we deal with hydrosalpinx first or transplant first? Harvard consultants introduced the "decision tree+Markov model" to quantify the probability of possible complications, time cost, and cost of each step into "expected values". If the expected value of "hysteroscopy on the third day after egg retrieval" is 2.4 points higher than "hysteroscopy before egg retrieval", the system will automatically mark it in red. The patient received a Gantt chart with traffic lights instead of vague textual suggestions.
4. Environment: Torrance Clinic creates a three-layer purification system consisting of "positive pressure+HEPA+molecular sieve" in the embryo laboratory and clinical operation area, with PM0.3 particles

3、 Cost model: Breaking down "uncontrollable" into "modular"

The biggest fear of going to the United States for IVF is the "temporary addition". INCINTA will break down all fees into 6 transparent modules in 2024, and lock the price upon signing. The USD quotation will be converted into RMB based on the exchange rate on the day of payment and written into the tripartite contract. The exchange rate fluctuations in the later period are not related to the patient.
Module A: Harvard Consultant Pre evaluation (including hormone three items, AMH, uterine artery blood flow, vitamin D, thyroid function, insulin resistance, genetic testing package) - original price of $1800, packaged price of $1200.
Module B: US ovulation promotion+egg retrieval+laboratory - $8900, including anesthesia, ICSI, time-lapse incubation, and AI assisted scoring.
Module C: Embryo Detection (PGT-A) - $2500 per piece, with a maximum of 8 pieces capped at $20000 without any additional charges.
Module D: One fresh embryo transfer+one frozen embryo transfer - $4600, including daily medication, ultrasound, and blood draw.
Module E: One year frozen storage - $1200, starting from the second year at $120 per tube per year.
Module F: Second transplant travel insurance to the United States - $1300, including flight rescheduling, hotel upgrade, medical translation, and 24-hour nurse on-site blood sampling.
Total: 1200+8900+20000+4600+1200+1300=37200 US dollars, equivalent to approximately 268000 RMB at the June 2024 exchange rate of 7.2. If the first transplant is successful, Module F can be refunded 50% and the actual payment is 260000 yuan. Compared to the current average of 150000 to 180000 yuan per third-generation test tube in China, it may seem like a premium, but considering the laboratory standards, drug purity, legal framework, and the fact that there are no additional charges for secondary transplantation in the United States, the overall cost is actually lower than "two domestic transplants+repeated absences+implicit surcharges".

4、 Risk List: Include 'Likelihoods' in the Contract

1. Ovarian hyperstimulation: INCINTA promises that if moderate or above OHSS occurs, all subsequent puncture, hospitalization, albumin, and anticoagulant treatment costs will be borne by the clinic, with no additional charges for patients.
2. Embryo detection failure: If none of the 8 embryos pass PGT-A, Module C will be fully refunded and the next round of ovulation induction drugs (worth $4000) will be provided free of charge.
3. Transplant failure: Both transplants did not result in clinical pregnancy. Module D will be refunded 50% and a hysteroscope and immunization kit (worth $2800) will be given as a gift.
4. Premature birth or obstetric complications: INCINTA has signed a green channel with Torrance Memorial Medical Center and UCLA Health, two NICU tertiary centers. The success rate of treating premature infants under 32 weeks is 97.4%, and the cost is covered by both commercial insurance and hospital charity funds. The maximum out of pocket payment for patients is $10000.
5. Legal risks: There are significant differences in assisted reproductive technology regulations among states in the United States, and California allows couples to sign contracts directly with clinics without the need for a third party. INCINTA has embedded a "legal clause change contingency insurance" in the contract. In case of policy changes that result in inability to continue, the clinic will bear the incurred expenses and reimburse the airfare.

5、 Timeline for Going to the United States: One Excel can handle it

Week 8: A basic physical examination will be conducted at a top tier hospital in China, with a 60 minute video provided by a Harvard consultant and a "Pre conditioning Prescription" issued.
Week 6: Start personalized combination of vitamin D, active folate, coenzyme Q10, DHEA, and insulin sensitizer.
Week 4: Apply for a visa, book a flight that can be changed, and make a reservation for Torrance Airbnb (a 10 minute walk to the clinic) simultaneously.
Week 2: Domestic re examination of hormone levels and ultrasound to confirm follicular synchrony, with Harvard consultant remotely locking in the date of entry into the week.
Day -1: Fly to Los Angeles, with entry materials including invitation letter, insurance policy, itinerary, and asset proof. Take the B2 channel, and the average clearance time is 8 minutes.
Day 1: Arrive at the clinic at 8am for blood draw and ultrasound, receive the ovulation promotion plan at 3pm, and start the first dose that evening.
Day 5: Recheck E2, LH, P4, AI model predicts follicle curve, and adjusts medication.
Day 9: Night needle, egg retrieval after 36 hours.
Day 10: Egg retrieval, synchronous ICSI, time-lapse incubation.
Day 15: Fresh or frozen embryo transfer. If the endometrium is>8 mm and the blood flow PI is between days 16-20: Stay in the United States for observation, draw blood to test for β - HCG, and confirm pregnancy before returning home; If not pregnant, immediately initiate a second transplant plan.
Day 21: Return, Harvard consultant will conduct video tracking every 3 days until fetal heart rate is observed at 7 weeks of pregnancy.

VI Q& A: Translate 'anxiety' into 'certainty'

Q1: I have already failed twice in China, what can I change by going to the United States?
A: The biggest difference between China and the United States is not "technology", but "decision-making granularity". Domestic hospitals have an average of 300 outpatient visits per day, and doctors give you 5 minutes; INCINTA daily initial consultation

Q2: What should I do if I don't understand the language?
A: The clinic is equipped with nurses who speak three languages (Chinese/English/Korean) as standard, accompanied by medical translators throughout the process. All reports are generated in bilingual PDF format, and key terms are interpreted by Harvard consultants' voice. On the day of transplantation, the nurse will teach you how to stuff medicine in a Chinese WeChat short video. After returning to China, domestic nurses will come to your home to draw blood, and the data will be directly transmitted to the US cloud.

Q3: Will the visa be rejected?
A: The B2 medical visa approval rate for 2024 is 93%. INCINTA provides a four piece set of "medical invitation letter+expense guarantee letter+itinerary+insurance policy". Consulates in Beijing, Shanghai, and Guangzhou can use the "medical urgent channel", with an average of 3 working days for visa approval. If the visa is refused, all fees for module A will be refunded.

Q4: How can I apply for my child's household registration, passport, and travel document when they return to China in the future?
A: INCINTA has a dedicated partner law firm that provides Level 3 certification for birth certificates, social security numbers, US passports, Chinese travel permits, and household registration templates. The process takes an average of 15 working days to complete and can be sent back to China via express delivery.

Q5: The man only has 2 days off, can he handle it?
A: The male party only needs to arrive 48 hours before the egg retrieval date, and can return immediately after the sperm retrieval on the same day. The clinic provides a backup solution of "vacuum negative pressure seminal vesicle+liquid nitrogen dry transportation". Even if the male cannot be present, domestic sperm collection and air transportation can be carried out in advance, which is recognized by California law.

7、 Next step: Transform "heartbeat" into "action"

From July to September 2024, INCINTA will open 30 sets of "Harvard 1-on-1" summer green channels to the China region, accompanied by complimentary "Los Angeles Shanghai" business class upgrade vouchers, 14 nights of Torrance sea view apartments, and 8 capped exemptions for embryo testing. Simply scan the code to submit the basic reports for AMH, hormones, and AFC, and receive a written evaluation from Harvard consultants within 48 hours. If the assessment is not suitable for going to the United States, module A fees are fully waived. Leave decisions to science, leave time to family, and entrust anxiety to algorithms - perhaps this is the true meaning of the 'New Path to IVF in the United States'.

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